Last edited by Kabar
Monday, May 11, 2020 | History

3 edition of Human drug metabolism found in the catalog.

Human drug metabolism

Human drug metabolism

from molecular biology to man

  • 87 Want to read
  • 16 Currently reading

Published by CRC Press in Boca Raton .
Written in English

    Subjects:
  • Drugs -- Metabolism.,
  • Drugs -- Metabolic detoxification.,
  • Biotransformation.,
  • Drugs -- metabolism.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Elizabeth H. Jeffery.
    SeriesPharmacology and toxicology, Pharmacology & toxicology (Boca Raton, Fla.)
    ContributionsJeffery, Elizabeth H.
    Classifications
    LC ClassificationsRM301.55 .H86 1992
    The Physical Object
    Pagination158 p. :
    Number of Pages158
    ID Numbers
    Open LibraryOL1720554M
    ISBN 100849378109
    LC Control Number92023798

    Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion. May 24,  · The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as Cited by:

    Jun 01,  · Human Drug Metabolism: An Introduction, Second Edition is a completely revised and updated version of this key text. Providing an invaluable introduction to this core area of pharmacology and covering recent progress and advances in this fast moving field/5(3). This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity.

    Oct 19,  · Human Drug Metabolism, An Introduction, Second Editionprovides an accessible introduction to the subject and will beparticularly invaluable to those who already have someunderstanding of the life ktexcleaning.comtely revised and updatedthroughout, the new edition focuses only on essential chemicaldetail and includes patient case histories to illustrate theclinical . Human Drug Metabolism Quotes Showing of 1 “It has been said that if a drug has no side effects, then it is unlikely to work. Drug therapy labours under the fundamental problem that usually every single cell in the body has to be treated just to exert a beneficial effect on .


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Human drug metabolism Download PDF EPUB FB2

Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

Human Drug Metabolism, Third Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology.

It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to Cited by: Human Drug Metabolism book.

Read 2 reviews from the world's largest community for readers. Drug metabolism is a core area of pharmacology. Before any dru /5. Oct 10,  · Human Drug Metabolism: An Introduction, Second Edition is a completely revised and updated version of this key text. Providing an invaluable introduction to this core area of pharmacology and covering recent progress and advances in this fast moving field.5/5(2).

Human Drug Metabolism: An Introduction by Michael D. Coleman. Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body.

Dec 24,  · Synopsis Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and ktexcleaning.com: Michael D.

Coleman. Online shopping from a great selection at Books Store. Handbook of Drug Metabolism, Third Edition (Drugs and the Pharmaceutical Sciences). Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences.

Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes. Nov 01,  · This first-edition soft-cover text provides a basic review of general principles of human drug metabolism and the impact of metabolism on therapeutic outcome.

The book is designed for an undergraduate audience and assumes only a basic knowledge of Author: M. Stalker. Drug metabolism [1] is an extremely CYP1, CYP2, and CYP3 [1] are involved in human drug metabolism amongst them CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 appear to be.

May 17,  · Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical Author: Michael D.

Coleman. Early knowledge of the human metabolism of a new drug is desirable for two main reasons: (1) drug metabolism is the major determinant of the pharmacokinetics and interactions with other compounds; and (2) species differences in metabolism are often responsible for the difficulties in extrapolating from laboratory animals to humans.

98, Feb 22,  · Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine.

This new text provides a concise, user-friendly introduction to drug metabolism that is 5/5(1). Get this from a library. Human drug metabolism: an introduction. [Michael D Coleman] -- (Publisher-supplied data) Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some.

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug Cited by: 8.

Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity.

Illustrates the growing relationship between drug metabolism and personalized medicine; Includes recent developments in drug discovery, genomics, and stem cell technologies; Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and.

between drug structure and metabolism, as well as providing examples of how metabolic stability studies have contributed to the design of drugs with improved bioavailabilities and favourable half-lives. In the final chapter of this book dealing with drug design, we return to this topic and.

(sirolimus is a known CYP3 A4 and P-glycoprotein substrate. Impairment of the CYP3 A4 enzyme-mediated metabolism of sirolimus, may lead to elevations in sirolimus blood concentrations and toxicity.

{01} The drug interactions between sirolimus and cyclosporine have been observed clinically in either patients or healthy human subjects. {01} {06}). Topics on Drug Metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Topics covered includes: Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability, Pharmacogenetics and Metabolism, Altered Drug Metabolism and Transport in Pathophysiological Conditions, Anticancer Drug Metabolism: Chemotherapy Resistance and New.

The liver plays a central role in metabolism of nutrients, synthesis of glucose and lipids, and detoxification of drugs and xenobiotics. The major pathways in the liver are glucose, fatty acids.Human Drug Metabolism. Instant. Rewards. Branded. Help.This book is intended to provide a basic grounding in human drug metabolism, although it is useful if the reader has some knowledge of biochemistry, physiology and pharma-cology from other sources.

In addition, a qualitative understanding of chemistry can illuminate many facets of drug metabolism and toxicity. Although chemistry can be.